Imipramine poisoning.

Treatment of severe imipramine poisoning.

The clinical effects and treatment of imipramine and amitriptyline poisoning have been reviewed by Giles (1963) and Steel, O'Duffy, and Brown (1967). The majority of cases are mild and recover spontaneously. The severe case is characterized by coma, convulsions, and cardiac arrhythmias. There is the added risk of respiratory depression and hypotension. Poisoning is severe if the dose of the dru...

Amitriptyline and imipramine poisoning in children.

The increasing number of children admitted to this hospital with poisoning by tricyclic antidepressants is causing concern. Of 60 children admitted between January 1966 and July 1973, half were admitted in the last 18 months. In 60% of these patients the tricyclic compounds had been prescribed for nocturnal enuresis. One child aged 2 years and 4 months died of imipramine poisoning. It is impera...

Imipramine poisoning: survival of a child after prolonged cardiac massage.

Acrocyanosis due to imipramine.

An 11 year old girl who was being treated for enuresis with imipramine developed acrocyanosis of the hands and feet. All biochemical and haematological investigations gave normal results. When imipramine was stopped the girl recovered within three days.

Antiacetycholine action of imipramine.

Imipramine, a potent antidepressive drug has been shown to antagonize the actions of a number of autopharmacological substances like histamine, 5-hydroxytryptamine, bradykinin, catecholamines and acetylcholine (1). Sigg and his coworkers (2, 3) observed a dual effect of imipramine on the various manifestations of the autonomic nervous system; a blocking action at higher dosage and a stimulant e...